Is QTL a genetic marker?
Data for mapping QTL consist of types of a number of polymorphic genetic markers and quantitative trait values for a number of individuals.
What does QTL stand for genetics?
Quantitative trait locus
Quantitative trait locus (QTL) analysis is a statistical method that links two types of information—phenotypic data (trait measurements) and genotypic data (usually molecular markers)—in an attempt to explain the genetic basis of variation in complex traits (Falconer & Mackay, 1996; Kearsey, 1998; Lynch & Walsh, 1998).
What is the difference between gene and QTL?
A quantitative trait locus (QTL) is a region of DNA which is associated with a particular phenotypic trait, which varies in degree and which can be attributed to polygenic effects, i.e., the product of two or more genes, and their environment. These QTLs are often found on different chromosomes.
What is QTL in evolution?
Quantitative trait loci (QTL) mapping has been used in a number of evolutionary studies to study the genetic basis of adaptation by mapping individual QTL that explain the differences between differentiated populations and also estimating their effects and interaction in the mapping population.
What is the importance of heritability in QTL mapping?
The estimated overall heritability of each trait may be considered as evidence of a genetic contribution to the total phenotypic variation, which implies the possibility of mapping genome regions responsible for the gene expression variation via linkage analysis.
Are the effects of QTL alleles context dependent?
If the effects of QTL alleles differ in their magnitude or direction in different genetic backgrounds, different environments or between males and females, they are said to be context dependent.
Can we map the QTLs of the human genome?
The landmark paper by Lander and Botstein 6 launched an avalanche of studies mapping QTLs, which has culminated in recent large-scale genome-wide maps of QTLs that affect human quantitative traits and diseases 7, 8, 9.
Can interval mapping of QTLs be performed using molecular markers?
This seminal paper describes a statistical method for interval mapping of QTLs using molecular markers and provides the first power calculations for these studies. Altshuler, D., Daly, M. J. & Lander, E. S. Genetic mapping in human disease. Science 322, 881–888 (2008).
How does QTL affect fiber length in plant cells?
The QTL increased 0.31 mm fiber length (FL) on average, suggesting the significant roles and important regions for FL. In addition, qLP-Chr5–3 and qBNP-Chr5–2 increased the lint percentage and the boll number per plant, along 333 kb (48 genes) pleiotropic regions along the SSR marker TMB1296 (Ma et al. 2019 ).