Is a lethal infection with the dengue fever virus?
Dengue is a mosquito-borne viral infection causing a severe flu-like illness and, sometimes causing a potentially lethal complication called severe dengue.
What is the receptor for dengue?
Dengue virus uses human mannose-binding receptor (MR) and DC-SIGN on macrophages as primary receptors, and CLEC5A as signaling receptor to sense the dengue virus invasion and then to signal and stimulate macrophages to secrete cytokines.
How the immune system defeat the dengue virus?
To fight the infection, the immune system produces antibodies to neutralize the dengue viral particles, and the complement system is activated to help the antibodies and white blood cells remove the virus. The immune response also includes cytotoxic T cells (lymphocytes), which recognize and kill infected cells.
Is dengue a self limiting disease?
Dengue fever is a self-limiting, nonspecific illness characterized by fever, headache, myalgia, and constitutional symptoms. Its severe forms (hemorrhagic fever and shock syndrome) may lead to multisystem involvement and death.
Does dengue cause death?
About 1 in 20 people who get sick with dengue will develop severe dengue. Severe dengue can result in shock, internal bleeding, and even death.
What is the death rate of dengue fever?
Dengue fever is a febrile illness caused by 1 of 4 serotypes of the virus, which may progress to dengue hemorrhagic fever or dengue shock syndrome. The mortality rate of untreated dengue shock syndrome is more than 20%.
How does dengue virus spread?
Through Mosquito Bites Dengue viruses are spread to people through the bites of infected Aedes species mosquitoes (Ae. aegypti or Ae. albopictus). These are the same types of mosquitoes that spread Zika and chikungunya viruses.
What is the structure of dengue virus?
The dengue virus has a roughly spherical structure. It is composed of the viral genome and capsid proteins surrounded by an envelope and a shell of proteins. After infecting a host cell, the dengue virus hijacks the host cell’s machinery to replicate the viral RNA genome and viral proteins.
What causes death due to dengue?
Among the 20 patients who died after one week of hospitalization, the major causes of death were secondary infections (n = 10 [50%]), renal failure (n = 2 [10%]), and respiratory failure (n = 2 [10%]). Four (20%) patients died of severe dengue.
Why does dengue cause death?
Severe dengue happens when your blood vessels become damaged and leaky. And the number of clot-forming cells (platelets) in your bloodstream drops. This can lead to shock, internal bleeding, organ failure and even death. Warning signs of severe dengue fever — which is a life-threatening emergency — can develop quickly.
Who is most at risk for dengue fever?
In hyperendemic areas in Asia, dengue fever (DF) and dengue haemorrhagic fever (DHF) affect mainly children under 15 years of age. The age distribution is different in the Americas where these syndromes occur in all age groups, although the majority of fatalities during epidemics occur in children.