Are carbapenems narrow spectrum?

The carbapenems are beta-lactam antimicrobial agents with an exceptionally broad spectrum of activity.

Are carbapenems broad or narrow spectrum?

Carbapenems display broad-spectrum activity against Gram-negative bacteria and slightly reduced activity against Gram-positive infections.

What are the carbapenem drugs?


  • Doribax.
  • doripenem.
  • ertapenem.
  • imipenem/cilastatin.
  • imipenem/cilastatin/relebactam.
  • Invanz.
  • meropenem.
  • meropenem/vaborbactam.

Is meropenem broad or narrow spectrum?

Meropenem is a broad-spectrum carbapenem antibiotic that possesses excellent activity against both aerobic Gram-positive and aerobic Gram-negative bacteria, and also covers common anaerobes.

Is aztreonam a carbapenem?

Imipenem (a carbapenem) is active against essentially all pathogenic organisms, but aztreonam (a monobactam) is active against only aerobic gram-negative bacilli.

Is imipenem broad spectrum?

Imipenem and meropenem have an exceptionally broad spectrum of activity. The bacterial species considered resistant to these drugs are MRSA, methicillin-resistant S. epidermidis, Stenotrophomonas maltophilia, Burkholderia cepacia, and E.

What is another name for carbapenem?

List of Carbapenems:

Drug Name Avg. Rating Reviews
Invanz (Pro) Generic name: ertapenem 5.5 2 reviews
Primaxin IM (Pro) Generic name: cilastatin / imipenem 10 1 review
Doribax (Pro) Generic name: doripenem 10 1 review
Primaxin IV (Pro) Generic name: cilastatin / imipenem 9.0 No reviews

Is ertapenem broad spectrum?

Spectrum: Like its big brother (Imipenem), ertapenem has a very broad spectrum of activity that includes all anaerobes and many aerobic gram-positive and gram-negative organisms. It has poor activity against P aeruginosa and Acinetobacter and lacks activity against Enterococcus faecium, S. epidermidis, B. Lepacia, S.

Is meropenem a carbapenem?

Imipenem and meropenem, members of the carbapenem class of β-lactam antibiotics, are among the most broadly active antibiotics available for systemic use in humans.

Is imipenem a narrow spectrum antibiotics?

Imipenem has the widest spectrum of antimicrobial activity of currently available beta-lactam agents and, in contrast to other beta-lactam antibiotics, lacks cross resistance with recently introduced extended-spectrum penicillins and third-generation cephalosporins.

What is the difference between meropenem and ertapenem?

Invanz (ertapenem) is an antibiotic that’s usually only given in hospital for serious infections. Treats bacterial infections. Merrem (meropenem) is an antibiotic that’s usually only given in the hospital for serious infections. It can be given at home, but you’ll have to be taught how to inject it correctly.

Do carbapenems have a broad spectrum of activity?

Comparative review of the carbapenems The carbapenems are beta-lactam antimicrobial agents with an exceptionally broad spectrum of activity. Older carbapenems, such as imipenem, were often susceptible to degradation by the enzyme dehydropeptidase-1 (DHP-1) located in renal tubules and required co-administration with a DHP-1 inhibitor su …

What are carbapenem antibiotics?

Furthermore, carbapenems are typically unaffected by emerging antibiotic resistance, even to other beta-lactams. Carbapenem antibiotics were originally developed at Merck & Co. from the carbapenem thienamycin, a naturally derived product of Streptomyces cattleya.

Can carbapenems be used to treat multidrug-resistant Gram-negative organisms?

This development is concerning because carbapenems are often the last resort for treating multidrug-resistant gram-negative organisms, particularly those that produce AmpC and extended-spectrum beta-lactamases, which destroy most beta-lactams except for carbapenems.

Is there any research paper on carbapenem resistance?

Recently, there has been a plethora of research information on carbapenem resistance, however, there are few comprehensive review papers discussing the research information. This paper therefore seeks to provide an in-depth review of carbapenem resistance providing up-to-date information on the subject. 2. Carbapenem Antimicrobials