Do the benefits of Prolia outweigh the side effects?

The NWHN is concerned that for most postmenopausal women, the benefit of denosumab does not outweigh the risks. We recommend that women seeking osteoporosis treatment approach denosumab with caution.

How long can you take Prolia for osteoporosis?

How long can I stay on Prolia for? For Prolia to work well at reducing fractures it needs to be taken long term and in one phase 2 clinical trial it has been used safely for up to 8 years with substantial increase in bone density, although most clinical trials are for 3 or 4 years.

How long can you have side effects from Prolia?

by Drugs.com Some may go away or get worse or new side effects may develop as treatment goes on. Prolia stays in your body for over 4 months so some of these side effects can last a long time. Another side effect of Prolia is that it can cause an increase in bone breaks when you stop using it.

Can Prolia cause weight gain?

Weight gain itself wasn’t reported as a side effect during clinical trials of Prolia. However, some people taking Prolia did have swelling in their arms or legs. And with swelling, your body weight can be quickly increased.

What is the success rate of Prolia?

Subjects treated for 10 years with denosumab achieved an average cumulative 10-year gain in BMD of 21.7 percent at the lumbar spine and 9.2 percent at the total hip, compared to baseline in the pivotal Phase 3 fracture study.

What is the alternative to taking Prolia?

Are there alternatives to Reclast and Prolia for osteoporosis? There are several other medications that can be used to treat and/or prevent osteoporosis, such as: Other bisphosphonates besides Reclast: Examples of others include ibandronate (Boniva) and alendronate (Fosamax).

What are the side effects of taking Prolia?

Blood in the stool

  • change in bowel habits
  • clear or bloody discharge from the nipple
  • constipation
  • darkened urine
  • difficulty with eating
  • dimpling of the breast skin
  • indigestion
  • inverted nipple
  • itching,pain,redness,swelling,tenderness,or warmth on the skin
  • Do Prolia side effects ever go away?

    Usually, but it depends. Some side effects of Prolia may go away on their own within a few days or weeks after starting treatment. Other side effects may continue for as long as you receive the medication, but they can often be relieved with other treatments.

    Is Prolia worth the side effects?

    This drug has a long list of side effects and it’s also important to note that long-term risks are unknown. The FDA Medication Guide lists the potential health problems, which include serious infections, thighbone fractures, and jaw bone problems. It is unclear if the benefits outweigh the risks.

    How dangerous is Prolia?

    Yes, Prolia does appear to weaken your immune system. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including endocarditis and serious infections of the skin, abdominal, urinary tract, and ear.

    https://www.youtube.com/watch?v=DhQ4QGwiP0g