How do you administer Gemzar?
The recommended dosage of GEMZAR is 1000 mg/m2 intravenously over 30 minutes on Days 1 and 8 of each 21-day cycle in combination with carboplatin AUC 4 administered intravenously on Day 1 after GEMZAR administration.
How do you give a gemcitabine injection?
The recommended dose for gemcitabine is 1000 mg/m2, given by 30-minute infusion. The dose should be given on Days 1, 8 and 15 of each 28-day cycle in combination with cisplatin. Cisplatin is given at a recommended dose of 70 mg/m2 on Day 1 following gemcitabine or day 2 of each 28-day cycle.
How long does it take to administer gemcitabine?
You have gemcitabine into your bloodstream (intravenously). It takes about 30 minutes. You might have treatment through a long plastic tube that goes into a large vein in your chest. The tube stays in place throughout the course of treatment.
How is gemcitabine Abraxane administered?
This treatment is usually given in an outpatient infusion center, allowing the person to go home afterwards. These drugs are repeated every 28 days. This is known as one Cycle. Each cycle may be repeated up to six times (six months), depending upon response, tolerability, and number of cycles prescribed.
Can Gemzar be given peripherally?
The lyophilized formulation of gemcitabine should hence be used in peripheral intravenous infusion for the treatment of patients with cancer.
How do you dilute gemcitabine?
To reconstitute, add 5 mL of 0.9% Sodium Chloride Injection to the 200-mg vial or 25 mL of 0.9% Sodium Chloride Injection to the 1-g vial. Shake to dissolve.
How do you reconstitute gemcitabine?
How long does Gemzar infusion take?
The recommended dose of Gemzar is 1000 mg/m² as an intravenous infusion over 30 minutes on Days 1 and 8 of each 21-day cycle, in combination with carboplatin AUC 4 intravenously after Gemzar administration on Day 1 of each 21- day cycle.
Does gemcitabine cross the blood brain barrier?
Most commonly used cytotoxic chemotherapy agents (namely taxanes and vinorelbine, but also pemetrexed and gemcitabine) do not readily cross the intact blood-brain barrier nor are they actively pumped out; responses occasionally reported may not be meaningful and will not treat micrometastatic disease.
How do you store gemcitabine?
Gemcitabine as the hydrochloride salt is stable for at least 7 days at concentrations of 0.1, 10, and 38 mg/mL in 5% dextrose injection and 0.9% sodium chloride injection stored at 32 degrees C during simulated ambulatory infusion.
How do you administer Gemzar for non small cell lung cancer?
Non-Small Cell Lung Cancer. The recommended dose of Gemzar is 1000 mg/m 2 intravenously over 30 minutes on Days 1, 8, and 15 in combination with cisplatin therapy. Administer cisplatin intravenously at 100 mg/m 2 on Day 1 after the infusion of Gemzar.
How often should I take Gemzar for pancreatic cancer?
Pancreatic Cancer. Recommended Dose and Schedule. The recommended dose of Gemzar is 1000 mg/m2 over 30 minutes intravenously. The recommended treatment schedule is as follows: Weeks 1-8: weekly dosing for the first 7 weeks followed by one week rest. After week 8: weekly dosing on Days 1, 8, and 15 of 28-day cycles.
How do you treat non hematologic adverse reactions to Gemzar?
Dosage Modifications for Non-Hematologic Adverse Reactions. Withhold GEMZAR or reduce dose by 50% for other Grade 3 or 4 non-hematological adverse reactions until resolved. No dose modifications are recommended for alopecia, nausea, or vomiting.
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