How is Colace absorbed?
Laxative action: Docusate salts act as detergents in the intestine, reducing surface tension of interfacing liquids; this promotes incorporation of fat and additional liquid, softening the stool. Absorption: Absorbed minimally in the duodenum and jejunum.
Where is Colace metabolized?
Docusate is metabolized by the liver and undergoes extensive first-pass metabolism to both active and inactive metabolites.
Does Colace affect absorption of other meds?
In general, stool softeners should not be taken within 2 hours of other medications, since they may reduce the effectiveness of those medications. Talk with your doctor or pharmacist to verify that this is the case with the medications that you are taking.
Is docusate absorbed?
Docusate is not absorbed systemically 7,9. As the actions of docusate are local and it is not absorbed, the pharmacokinetic parameters are not available 9. If docusate is systemically absorbed, it undergoes biliary excretion 7,9. Docusate is not known to be carcinogenic or cause reproductive toxicity.
How is Colace metabolized and excreted?
It does not stay in the gastrointestinal tract, but is absorbed into the bloodstream and excreted via the gallbladder after undergoing extensive metabolism.
How does Colace work?
Colace acts as a surfactant and lowers the surface tension of oil and water in the stool. This allows lipids and moisture to penetrate the stool, producing a softer stool that can move more easily through the gastrointestinal tract.
Is Colace absorbed?
Docusate calcium is administered orally; docusate sodium is administered orally and rectally. Because docusate salts are minimally absorbed and exert their effects locally, standard pharmacokinetic parameters do not apply.
Do stool softeners interfere with medications?
Oral laxatives may interfere with your body’s absorption of some medications and nutrients. Some laxatives can lead to an electrolyte imbalance, especially after prolonged use.
What drugs does Colace interfere with?
Medications known to interact with Colace
- lactulose.
- linaclotide.
- mineral oil.
- phenolphthalein.
What is the mechanism of action of Colace?
It works by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass.
How do stool softeners work?
Stool softeners are a type of laxatives used for treating constipation. They act by reducing the surface tension of the stools and allowing water and oil to enter the stool mass causing it to soften, which is then easier to pass.
When is the best time to take Colace?
Take this medication by mouth, usually at bedtime with a full glass (8 ounces or 240 milliliters) of water or juice, or as directed by your doctor. The dosage is based on your medical condition and response to therapy. Decrease your dose or stop taking this medication if you develop diarrhea.