Is Prolia a RANKL inhibitor?

Prolia® is the first FDA approved RANK Ligand inhibitor for postmenopausal women with osteoporosis at high risk for fracture. Find out how Prolia® works as an antiresorptive treatment. Prolia® is an antiresorptive RANK Ligand inhibitor, and its mechanism of action makes it different than a bisphosphonate.

What is the difference between bisphosphonates and denosumab?

The difference between denosumab and bisphosphonates for clinical outcomes were change in the skeletal BMD. Denosumab has a greater antiresorptive effect than bisphosphonates. The effects of bisphosphonates for preventing bone loss mainly need bisphosphonates binding to bone mineral.

How does RANKL cause osteoporosis?

RANKL as a Promising Therapeutic Target for Osteoporosis It owns a carboxy-terminal domain that is homologous to TNF, and it is expressed on the cell surface of osteoblasts, resulting in cell-to-cell-dependent contact with osteoclast precursor cells to promote the formation of osteoclasts.

What is the drug denosumab used for?

Denosumab injection (Prolia) is used to treat bone loss in men who are being treated for prostate cancer with certain medications that cause bone loss, to treat bone loss in women with breast cancer who are receiving certain medications that increase their risk for fractures.

Is denosumab effective?

Denosumab has been shown to increase BMD and decrease fracture risk in postmenopausal women with osteopososis. A recent meta-analysis showed that denosumab was associated with a 42% reduction in the incidence of fractures in postmenopausal women as compared with placebo.

Does denosumab increase bone density?

Denosumab causes somewhat greater increases in bone mineral density (BMD) than the class of bisphosphonate antiresorptives. Denosumab also causes an increase in bone mass and bone strength in the spine, ultradistal and diaphysis of the radius, proximal tibia and the hip.

Is denosumab better than alendronate in the treatment of osteoporosis?

These RCTs, conducted in postmenopausal women, regardless of prior treatment for osteoporosis, both found denosumab to be more efficacious than alendronate in increasing BMD, possibly the best proxy outcome for subsequent fracture risk.

How much is denosumab cost?

The list price for Prolia® is $1,434.14* ,† per treatment every six months. Most patients do not pay the list price. Your actual cost will vary. Talk to your insurance provider.

How much does denosumab cost UK?

Prolia 60mg/1ml solution for injection pre-filled syringes (Amgen Ltd)

Active ingredients Size Drug tariff price
Denosumab 60 mg per 1 ml 1 £183.00

What is the monoclonal antibody used for the treatment of osteoporosis?

Denosumab is the only monoclonal antibody approved by the FDA as a therapy for osteoporosis. Clinical studies indicate that the treatment of osteoporotic patients with denosumab for a 10-year period leads to a continuous increase in bone mineral density (BMD) with a low incidence of adverse effects.

What is the mechanism of action of Prolia?

Prolia prevents RANKL from activating its receptor, RANK, on the surface of osteoclasts and their precursors. Prevention of the RANKL/RANK interaction inhibits osteoclast formation, function, and survival, thereby decreasing bone resorption and increasing bone mass and strength in both cortical and trabecular bone.

What is Denosumab and RANKL pathway?

The RANKL Pathway and Denosumab. Denosumab (Prolia) is a fully human monoclonal antibody directed against receptor activator of nuclear factor-κB ligand (RANKL), which interferes with the formation, activation, and survival of osteoclasts.

Does denosumab modulate bone remodeling by modulating bone modulation?

These results suggest that the modulation of bone remodeling by denosumab may result in a pattern of effects on cortical bone that may be beneficial. Whether this observation will result in greater fracture reduction in cortical bone compared with other antiresorptive therapy is unknown.

What are the side effects of denosumab and placebo?

The overall incidence of adverse events during the 24 months was similar between the placebo and denosumab groups. The most common adverse events in both treatment groups were arthralgia, nasopharyngitis, and back pain, with more subjects on denosumab reporting sore throat and rashes.

What is the drug class for denosumab?

Drug class: RANKL Inhibitors. DENOSUMAB slows bone breakdown. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. Xgeva is used to treat a high calcium level due to cancer and to prevent bone fractures and other bone problems caused by multiple myeloma