What causes Bcl-2 overexpression?
The results suggest that gene amplification and translocation are at least equally common mechanisms causing bcl-2 protein overexpression in DLBCL. Bcl-2 protein overexpression as determined by IHC is associated with poor response to chemotherapy and poor survival.
Is Bcl-2 a growth factor?
Bcl2 may act as a ‘survival sensor’ Diacylglycerol, a potent PKC agonist, induces Bcl2 phosphorylation and promotes cell growth and proliferation. Conversely, ceramide induces Bcl2 dephosphorylation and promotes growth arrest and cell death.
What does the Bcl-2 gene do?
The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of intermembrane space proteins, subsequent caspase activation and apoptosis.
What does BCL2 positive mean?
The gene for BCL2 is found on chromosome 18, and transfer of the BCL2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas. This causes the BCL2 protein to be made in larger amounts, which may keep cancer cells from dying. Also called B-cell leukemia/lymphoma 2 protein.
What is a BCL2 inhibitor?
A selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon administration, Bcl-2 inhibitor BCL201 binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells.
How does BAD promote apoptosis?
BAD, as one of the “death-promoting” members of the Bcl-2 family [4], is activated through dephosphorylation responsible for apoptotic event, in contrast, inactivation promote cell survival through phosphorylation on several serine residues by upstream kinase, such as Akt, Raf, Pim-2, and PKA [3, 5].
How Bcl-2 can induce or inhibit cell death?
Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death. Apoptosis.
Is BCL2 a tumor suppressor gene?
Bcl-2 is widely believed to be an apoptosis suppressor gene. Overexpression of the protein in cancer cells may block or delay onset of apoptosis, by selecting and maintaining long-living cells and arresting cells in the G0 phase of the cell cycle.