What is anhydrous DMF?
Anhydrous DMF (Dimethylformamide) is used for solubilizing S-HyNic, S-4FB, and other SoluLINK linkers. Anhydrous DMF is packaged with molecular sieves to minimize water contamination and preserve quality.
What is the use of DMF?
This high solubility of inorganic substances also leads to the application of DMF in the production of high voltage capacitors. DMF is also used as carrier for inks and dyes in various printing and fiber-dying applications. DMF is widely used as a solvent, reagent and catalyst in the synthetic organic chemistry.
What type of solvent is DMF?
DMF is a polar (hydrophilic) aprotic solvent with a high boiling point. It facilitates reactions that follow polar mechanisms, such as SN2 reactions.
Is DMF toxic?
DMF is a potent liver toxin. DMF may cause abdominal pain, constipation, nausea and vomiting, headache, weakness, dizziness, skin problems, and alcohol intolerance. Current evidence associating DMF with cancer in humans is not conclusive.
How do you make anhydrous DMF?
Dry DMF can be prepared by drying overnight over barium oxide or 4A molecular sieves, followed by decantation of the drying agent and vacuum distillation (~20 mmHg is a sufficient vacuum to lower the boiling point over DMF to a reasonable value).
Is DMF a green solvent?
The equal weighting of environmental, health and safety issues could be debated, for the reprotoxic DMF (3.7) registers as greener than peroxide forming ether solvents such as diethyl ether (3.9).
What is the common name used for DMF?
Dimethylformamide is an organic compound with the formula (CH3)2NC(O)H. Commonly abbreviated as DMF (although this initialism is sometimes used for dimethylfuran, or dimethyl fumarate), this colourless liquid is miscible with water and the majority of organic liquids. DMF is a common solvent for chemical reactions.
Does DMF dissolve in water?
DMF is soluble in water, you can extract with ether,DMF slighty soluble in ethyl acetate.
Does DMF go through nitrile gloves?
Neither latex nor nitrile gloves provide adequate protection against DMF.
Is DMF basic or acidic?
In pubchem, i found the pKa of DMF is -0.3. However it is a strong base, which means its pKa value should be high (>16).
How do you remove water from DMF?
If your product is not dangerously polar, dilute with lots and lots of water before extracting with a nonpolar solvent. Then thoroughly wash the organic layer with water. Rule of Thumb ( see all): For 5 mL of DMF or DMSO, use 5 X 10 mL of water during the aqueous wash. This should remove all of the DMF or DMSO.
How do you evaporate a DMF solvent?
Extract the product in ethyl acetate, then give water wash as dmf is more soluble in water compared to ethyl acetate. Simply by evaporation under a good vacuum (rotary evaporator with oil pump). You dissolve your sample in what you want (or even suspend) and evaporate to dryness. Then repeat this step sevaral times.
What is the CAS number for DMF anhydrous?
N,N-Dimethylformamide anhydrous, 99.8%; CAS Number: 68-12-2; EC Number: 200-679-5; Synonyms: DMF,NSC 5356; Linear Formula: HCON(CH3)2; find Sigma-Aldrich-227056 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich Products USEN Products ApplicationsProductsServicesSupport All Photos(1) 227056
What is DMF used for in chemistry?
General description N,N-Dimethylformamide (DMF) is the commonly employed solvent for chemical reactions. DMF is a useful solvent employed for the isolation of chlorophyll from plant tissues. It is widely employed reagent in organic synthesis.
What is the function of N N dimethylformamide in organic synthesis?
It is a multipurpose building block for the synthesis of compounds containing O, -CO, -NMe2, -CONMe2, -Me, -CHO as functional groups. N,N-Dimethylformamide is a polar solvent commonly used in organic synthesis. It also acts as a multipurpose precursor for formylation, amination, aminocarbonylation, amidation and cyanation reactions.