What is BMP-2 used for?
BMP-2 like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. It is also involved in cardiac cell differentiation and epithelial to mesenchymal transition.
Is BMP-2 a growth factor?
Bone morphogenetic proteins belong to the expanding transforming growth factor-beta superfamily. Bone morphogenetic protein-2 has pleiotropic functions that range from extraskeletal and skeletal organogenesis to bone generation and regeneration.
What is recombinant human bone morphogenetic protein 2?
The bone morphogenetic proteins (BMPs) are soluble bone matrix glycoproteins that induce the differentiation of osteoprogenitor cells into osteogenic cells and have the potential to act as autogenous bone graft substitutes.
What does BMP2 stand for?
The BMP-2 (Boyevaya Mashina Pekhoty, Russian: Боевая Машина Пехоты, literally “infantry combat vehicle”) is a second-generation, amphibious infantry fighting vehicle introduced in the 1980s in the Soviet Union, following on from the BMP-1 of the 1960s. BMP-2.
What is the BMP pathway?
BMPs can signal through both canonical and non-canonical pathways. In the canonical signaling pathway, they initiate the signal transduction cascade by binding to cell surface receptors and forming a heterotetrameric complex comprised of two dimers of type I and type II serine/threonine kinase receptors (Fig. 1B).
What is BMP bone graft?
BMP is Bone Morphogenetic Protein. The active ingredient in INFUSE Bone Graft — rhBMP-2 — is a manufactured version of a protein already present in the body that promotes new bone growth.
Is Bone Morphogenetic Protein Safe?
BMP is a naturally occurring human protein that was isolated and reproduced as a result of cutting-edge human gene research. Many studies have determined BMP may be a safe and effective alternative to autogenous iliac crest bone graft (autograft).
How much is a BMP-2?
|Average Unit Cost:||$1,564,885|
What are BMP antagonists?
Briefly, antagonists of BMPs include proteins such as noggin, chordin, gremlin, crossveinless, USAG-1 and follistatin. Most of these proteins are expressed in a highly regulated temporospatial manner during development.
What is BMP infuse?
How is BMP-2 synthesized?
Human Bone Morphogenetic Protein-2 (BMP-2) is synthesized as large precursor molecule (Met 1 -Arg 396, with a signal peptide from Met 1 to Gly 23 ), propeptide (Leu 24 -Arg 282) of which is cleaved by PCSK5 (Proprotein Convertase Subtilisin/Kexin type 5).
What is bone morphogenetic protein 2 (BMP-2)?
Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. BMP-2 like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage.
What is the role of BMP-2 in cell differentiation?
It is also involved in cardiac cell differentiation and epithelial to mesenchymal transition . Like many other proteins from the BMP family, BMP-2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types.
What is the molecular weight of BMP2?
BMP2 exhibits a Molecular Weight of approximately 26 kDa as revealed by SDS-PAGE (under non-reducing conditions). Endotoxin level was found to be <0.1 ng/µg (1EU/µg) by a LAL gel clot method.