What is buspirone?
What is buspirone? Buspirone is an anti-anxiety medicine that affects chemicals in the brain that may be unbalanced in people with anxiety. Buspirone is used to treat symptoms of anxiety, such as fear, tension, irritability, dizziness, pounding heartbeat, and other physical symptoms.
What receptors does buspirone act on?
Buspirone acts as an agonist of the serotonin 5-HT 1A receptor with high affinity. It is a partial agonist of both presynaptic 5-HT 1A receptors, which are inhibitory autoreceptors, and postsynaptic 5-HT 1A receptors.
What is the K I nm value of buspirone?
Values are K i (nM). The smaller the value, the more strongly the drug binds to the site. Buspirone acts as an agonist of the serotonin 5-HT 1A receptor with high affinity. It is a partial agonist of both presynaptic 5-HT 1A receptors, which are inhibitory autoreceptors, and postsynaptic 5-HT 1A receptors.
What is the role of grapefruit in the treatment of buspirone?
^ Lilja JJ, Kivistö KT, Backman JT, Lamberg TS, Neuvonen PJ (December 1998). “Grapefruit juice substantially increases plasma concentrations of buspirone”. Clinical Pharmacology and Therapeutics. 64 (6): 655–60. doi: 10.1016/S0009-9236 (98)90056-X. PMID 9871430.
What is the bioavailability of buspirone hydrochloride?
The single-dose bioavailability of unchanged Buspirone when taken as a tablet is on the average about 90% of an equivalent dose of solution, but there is large variability. The effects of food upon the bioavailability of Buspirone hydrochloride tablets have been studied in eight subjects.
Can buspirone hydrochloride tablets be taken with a monoamine oxidase inhibitor (MAOI)?
The administration of Buspirone hydrochloride tablets to a patient taking a monoamine oxidase inhibitor (MAOI) may pose a hazard. There have been reports of the occurrence of elevated blood pressure when Buspirone hydrochloride tablets have been added to a regimen including an MAOI.
Is buspirone safe for nurses to use?
In an era where drug abuse results in high mortality, the responsibility is on all healthcare workers to ensure that patients only use buspirone for legitimate purposes. The literature review suggests that buspirone has negligible abuse potential. [25] Nurses should monitor for the signs and symptoms of anxiety during each follow-up visit.