What is eudragit L100?

Abstract. Eudragit® L100 is a commonly used polymer in a coating layer of modified-release drug formulation to prevent drug release in the stomach. The amount of Eudragit® L100 in the formula determines the dissolution profile of drug at its release medium.

What is eudragit made of?

Introduction: Eudragit is the brand name for a diverse range of polymethacrylate-based copolymers. It includes anionic, cationic, and neutral copolymers based on methacrylic acid and methacrylic/acrylic esters or their derivatives.

Does eudragit swell?

A wide variety of EUDRAGIT® polymers for sustained release are available as granules, powders, aqueous dispersions or organic solutions for use with dosage forms including matrix tablets and multiparticulates. All are insoluble, with pH-independently swelling.

What is eudragit EPO?

Eudragit® E PO (EPO) is a terpolymer based on N,N-dimethylaminoethyl methacrylate with methylmethacrylate and butylmethacrylate, produced by Evonik Industries AG as a pharmaceutical excipient. In this work, EPO was chemically modified through reaction with acryloyl chloride.

What is eudragit used for?

Eudragit L-30D was introduced in 1972. It is soluble in intestinal fluid at a pH of 5.5 and the white, anionic, freely flowing form is used to make enteric coatings (Thakral et al., 2013). Kuang et al. used various enteric-coated polymers for preparing enteric-coated pellets of duloxetine hydrochloride.

What is eudragit L and S?

Eudragit L & Eudragit S are two forms of commercially available enteric acrylic resins. Both of them produce films resistant to gastric fluid. Eudragit L & S are soluble in intestinal fluid at pH 6 & 7 respectively. Eudragit L is available as an organic solution (Isopropanol), solid or aqueous dispersion.

How pH alteration of the drug microenvironment is done?

Explanation: Alteration of pH of the drug microenvironment is done in two ways. One of that is in-situ salt formation, and other is the addition of buffers to the formulation e.g. buffered aspirin tablets.

What are eudragit polymers?

Eudragit is a family of proprietary, targeted drug release coating polymers. These polymers allow drugs to be formulated in enteric, protective or sustained-release formulations to prevent break-down of the drug until it has reached an area with adequate pH in the gastrointestinal (GI) tract.

What is meant by pH sensitive?

pH sensitive or pH responsive polymers are materials which will respond to the changes in the pH of the surrounding medium by varying their dimensions. Materials may swell, collapse, or change depending on the pH of their environment.

How can you increase the solubility of a drug?

Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation, and so forth.

What is the composition of Eudragit L 100?

EUDRAGIT L 100 are anionic copolymers based on methacrylic acic and methyl methacrylate. Information for this product is unavailable at this time.

What are Eudragit® e Polymers?

EUDRAGIT® E polymers for immediate release are widely used by pharmaceutical companies to mask the taste or odor of their oral drug products. In addition to having a neutral taste and smell, they have a smooth, pleasant feel in the mouth with minimal amounts of polymer typically required to obtain the desired functionality.

Is Eudragit non biodegradable?

They are non-biodegradable, non-absorbable, nontoxic and amorphous polymer [83]. According to Evonik, all Eudragit polymers have thermoplastic properties, low glass transition temperatures (between 9 • C and > 150 • C), high thermostability, and high miscibility with APIs and other excipients [83,84].

What is the difference between Eudragit RL RS RS E 30D polymers?

The results indicate that the Eudragit RL, RS, or E 30D polymer exhibited a higher thermal-stable behavior, but Eudragit E easily formed the six-membered cyclic anhydride through heating process via the inter- or intramolecular ester condensation.