What is factor 2 clotting disorder?
What is Factor II deficiency? Factor II deficiency is a very rare blood clotting disorder. It results in excessive or prolonged bleeding after an injury or surgery. Factor II, also known as prothrombin, is a protein made in your liver. It plays an essential role in blood clot formation.
How common is Factor II mutation?
A change in the prothrombin gene is present in 2-4% (or 1 in 50 to 1 in 25) of Caucasians, and is more common in individuals of European ancestry. In the United States, approximately 0.4% (about 1 in 250) of African Americans also have the mutation.
What causes Factor II deficiency?
Acquired factor II deficiency can be caused by severe liver disease, vitamin K deficiency, anticoagulant drugs (eg, warfarin), or the presence of an antibody directed against the protein. Aside from the prothrombin deficiencies, another disorder of prothrombin is the prothrombin 20210a mutation.
How serious is prothrombin gene mutation?
Having the prothrombin mutation increases the risk of developing a DVT (a blood clot in the deep veins, typically the legs) and/or PE (blood clot that travels to the lungs). DVTs are dangerous because they can damage the veins, leading to pain and swelling, and sometimes to disability.
How many people in the world have factor 2?
The incidence is estimated at 1 in 2 million in the general population.
How do you test for Factor II deficiency?
Testing. Diagnosis is made with a prothrombin time (PT) test and an activated partial thromboplastin time (aPTT) test. Levels of prothrombin deficiency can range from 2% to 50% of normal. Patients with levels near or at 50% of normal have little to no bleeding problems.
What is the difference between factor 5 and factor 2?
The Factor V variant known as Factor V Leiden (or rs6025) is associated with an approximately 300% increased risk in heterozygotes and an up to 8000% increased risk in homozygotes. The Factor II rs1799963 polymorphism (or G20210A) may also independently increase the risk by approximately 200%.
What would happen if a blood clotting factor is missing?
Coagulation factors are known by Roman numerals (I, II VIII, etc.) or by name (fibrinogen, prothrombin, hemophilia A, etc.). If any of your factors are missing or defective, it can lead to heavy, uncontrolled bleeding after an injury.
Can you donate blood with factor 2 mutation?
Yes, you may be able to donate blood if you’re not taking a blood thinner. The mutation in itself is not a reason to avoid donating blood, but you should not give blood if you are using an anticoagulant (blood thinner). Check with your provider.
Is prothrombin gene mutation curable?
No treatment can prevent the prothrombin gene mutation or make it go away. The goal of treatment is to prevent blood clots (see next question and page 7). If you have had a blood clot, you may be treated with medications called anticoagulants. Anticoagulants are used to help to prevent blood clots.
How is factor 2 mutation treated?
There is no specific treatment for the mutation itself. If you develop a deep vein thrombosis or pulmonary embolism, your provider will prescribe an anticoagulant.
Which is worse Factor 5 or factor 2?
What causes high prothrombin time?
Bleeding disorders
What do high prothrombin levels mean?
Bone marrow problems
What are the 13 blood coagulation factors?
The following are coagulation factors and their common names: Factor I – fibrinogen. Factor II – prothrombin. Factor V – labile factor or proaccelerin. Factor VI – unassigned. Factor VII – stable factor or proconvertin. How many types of clotting factors are there?
What diseases are caused by gene mutations?
The brains of those with Alzheimer’s present amyloid plaques, which have a level of toxicity believed to cause neuron death. These plaques are formed when the amyloid precursor protein is cleaved by an enzyme called beta-secretase. “The Icelandic mutation makes it harder for this enzyme to cleave the amyloid precursor protein.