What is Lkm antibody test?
The liver kidney microsome type 1 antibody (anti-LKM-1 or CYP2D6 antibody) test is primarily used along with a smooth muscle antibody (SMA) and an antinuclear antibodies (ANA) test to help diagnose autoimmune hepatitis and to differentiate between the two major types, type 1 and type 2.
What is LKM-1 antibody IgG?
Liver Kidney Microsomal (LKM-1) Antibody (IgG) – The presence of LKM-1 antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of autoimmune liver diseases such as autoimmune hepatitis (AIH-2).
What is actin smooth muscle antibody test for?
How is it used? The smooth muscle (SMA) or actin antibody test is primarily ordered along with antinuclear antibodies (ANA) and liver kidney microsomal type 1 (LKM-1) antibodies to help diagnose autoimmune hepatitis and to differentiate between the two major types of autoimmune hepatitis, type 1 and type 2.
What labs are abnormal in autoimmune hepatitis?
Your doctor will use blood tests to look for evidence of autoimmune hepatitis. Blood tests include tests that check levels of the liver enzymes alanine transaminase (ALT) and aspartate transaminase (AST) and check for autoantibodies such as antinuclear antibody (ANA) and anti-smooth muscle antibody (SMA).
What is liver kidney microsome?
The antibody is called liver kidney microsomal antibody. Having this antibody may mean that your child has liver damage caused by a form of hepatitis. Hepatitis is a condition in which the liver is inflamed. Some types of hepatitis are caused by a hepatitis virus.
What does a positive anti-smooth muscle antibody mean?
What Does a Positive Smooth Muscle Antibody Test Mean? Normally, very little to no ASMAs are found in your blood. If your blood test shows a high amount of ASMAs, you may have autoimmune hepatitis. It means that your immune system is attacking healthy cells in your liver using autoantibodies.
What is Type 2 autoimmune hepatitis?
There are two types of autoimmune hepatitis: type 1 is characterized by increased levels of anti-nuclear antibodies (ANA) and anti-smooth muscle antibodies (ASMA); and type 2 autoimmune hepatitis is characterized by increased levels of anti-liver/kidney microsomal antibodies (anti-LKM) and anti-liver cytosol 1 (ALC 1) …
What causes anti-smooth muscle antibodies?
An ASMA test looks for the one type of autoantibody that attacks smooth muscle. Anti-smooth muscle antibodies are found in autoimmune liver diseases such as primary biliary cholangitis and autoimmune hepatitis (AIH).
What does it mean if IgG is positive and IgM is negative?
IgM positive, IgG negative: This suggests infection in the early stages of the disease. The patient is infectious. If the result does not coincide with the clinical picture (for example, if there are no symptoms) it could be a false positive.
What is an anti LKM antibody?
An anti-LKM antibody ( anti–liver-kidney microsomal antibody or LKM antibody) is any of several autoantibodies that are detected in the serum of patients with different types of acute or chronic liver disease. These antibodies are targeted against antigens of the cytochrome P450 system.
What are anti-LKM-1 antibodies?
Liver kidney microsome type 1 (anti-LKM-1) antibodies are autoantibodies, proteins produced by the body’s immune system that recognize and target its own enzyme called cytochrome P450 2D6 (CYP2D6), a protein found primarily in liver cells. The development of anti-LKM-1 antibodies is strongly associated with type 2 autoimmune hepatitis.
What is liver kidney microsome type 1 (anti-LKM-1)?
What is being tested? Liver kidney microsome type 1 (anti-LKM-1) antibodies are autoantibodies, proteins produced by the body’s immune system that recognize and target its own enzyme called cytochrome P450 2D6 (CYP2D6), a protein found primarily in liver cells.
What does it mean if my LKM test is negative?
If your results show a negative anti-LKM 1, but SMA and ANA tests are positive, it may mean that you have type 1 autoimmune hepatitis. However, if all are negative, it may be that your liver disease is not caused by autoimmune diseases. The possibility is, however, not ruled out as sometimes as not all people produce anti-LKM 1 or SNA antibodies.