What is Psadt?
A short PSA doubling time (PSADT) is known to predict both the development of metastasis (DM), prostate cancer-specific mortality (PCSM), and increased overall mortality (OM) in patients experiencing BF after RP [4–10].
Can biochemical recurrence be cured?
While many patients can be cured with definitive local therapy, some will have biochemical recurrence (BCR) of disease detected by a rising serum prostate-specific antigen (PSA). Management of these patients is nuanced and controversial.
What happens if PSA comes back?
A one-time, small rise in PSA might cause closer monitoring, but it might not mean that the cancer is still there (or has returned), as PSA levels can fluctuate slightly from time to time. However, a PSA that is rising on consecutive tests after treatment might indicate that cancer is still there.
Do you need hormone replacement after prostate removal?
Hormone therapy used alone is the standard treatment for men who have a prostate cancer recurrence as documented by CT, MRI, or bone scan after treatment with radiation therapy or prostatectomy.
Why does PSA double?
Doubled PSA score: Has your score doubled in a year? Speed of increase over time:The amount of PSA in the blood is measured in nanograms per milliliter. An increase greater than 0.35 nanograms is linked to a higher risk for prostate cancer. Focus on increases over time, or at least one year.
How fast does PSA double?
PSA doubling time is the number of months it would take for PSA to increase two-fold. The PSA doubling time of our example patient would therefore be 48 months.
What is mHSPC?
Metastatic hormone-sensitive prostate cancer (mHSPC) is when cancer has spread past the prostate into the body, but it can be treated with hormone therapy. This means that male sex hormones, including androgens like testosterone, can be blocked or stopped to slow cancer growth.
What causes biochemical recurrence?
A rise in the blood level of PSA (prostate-specific antigen) in prostate cancer patients after treatment with surgery or radiation. Biochemical recurrence may occur in patients who do not have symptoms. It may mean that the cancer has come back.
What does PSA 30 mean?
CONCLUSIONS: Serum PSA >30 ng/ml is an almost certain predictor of the presence of prostate cancer. Aggressive prostate cancer education and screening programs are needed in our inner cities in order to detect prostate cancer at an earlier, treatable stage.
Does prostate removal affect personality?
Following prostate cancer surgery men often experience physical changes, such as urinary incontinence and erectile dysfunction, causing negative emotions and distress. This review found that men felt poorly prepared – psychologically and physically – for the changes they might experience after surgery.