What is the SYT gene?

SYT and SYT-SSX are nuclear proteins that associate with chromatin remodeling complexes (SWI/SNF) and are thought to be involved in the control of gene expression (dos Santos et al., 2001; Ladanyi, 2001). The SSX gene family is composed of nine contiguous members (SSX1–9).

What is Synovial sarcoma?

Synovial sarcoma is a cancer that can come from different types of soft tissue, such as muscle or ligaments. It is often found in the arm, leg, or foot, and near joints such as the wrist or ankle. It can also form in soft tissues in the lung or abdomen. Synovial sarcoma may also be called malignant synovioma.

Does synovial sarcoma run in families?

Synovial sarcomas are made up of cells with genes that have errors (mutations) in them. These gene glitches don’t get passed down through families.

Does sarcoma run in families?

If you have many family members who have had sarcoma or other cancers at a young age, ask your doctor about genetic testing to see if you are at greater risk for developing a sarcoma. You may have inherited a gene that is defective if anyone in your family had one of these diseases. This disease runs in families.

Can sarcoma be passed on genetically?

Genetics. Hereditary conditions: Some rare, inherited genetic conditions are considered risk factors for soft tissue sarcoma. Speak with your doctor if you have a family history of any of the below conditions, or a history of sarcomas.

Are sarcoma tumors hereditary?

Who is most at risk of sarcoma?

Age. Soft tissue sarcomas can develop in people of all ages, but like most cancers, the risk increases as we get older. Around 40 in 100 soft tissue sarcomas (40%) are diagnosed in people aged 65 or older. Sarcoma can develop in children and young people.

Is sarcoma caused by smoking?

Injury and lifestyle factors such as smoking, diet, and exercise are NOT linked to the risk for soft tissue sarcoma . But the injury issue has caused some confusion in the past. One reason is that an injured area might swell. That swelling could look like a tumor, but it isn’t one.

What gene causes sarcoma?

The most common mutation that causes Ewing sarcoma involves two genes, the EWSR1 gene on chromosome 22 and the FLI1 gene on chromosome 11.