How do bacteria become resistant to linezolid?
The major mechanism of resistance to linezolid is caused by mutations in the V domain of the 23S rRNA gene, with a G2576T substitution (Escherichia coli numbering) occurring most frequently.
Can MRSA become resistant to linezolid?
Surveillance studies indicate that linezolid resistance is still extremely rare in both MRSA and CoNS clinical isolates. Recent epidemiological data show that linezolid resistance occurs in ≤1% of S. aureus isolates and ≤0.1% of CoNS in the US [62,76].
What MIC for MRSA is considered resistant to linezolid?
Most S. aureus isolates, including MRSA, are found to be linezolid susceptible, with a breakpoint of 4 μg/ml (3, 4). However, the emergence of linezolid-resistant MRSA with MICs of >4 μg/ml has been reported recently (1, 5, 6, 8, 11, 12).
Is Zyvox bacteriostatic or bactericidal?
Linezolid is bacteriostatic against most susceptible organisms but displays bactericidal activity against some strains of pneumococci, Bacteroides fragilis and C. perfringens. In clinical trials involving hospitalised patients with skin/soft tissue infections (predominantly S.
Is E coli resistant to linezolid?
Although the ribosomes of Escherichia coli are as susceptible to linezolid as those of Gram-positive cocci, linezolid MICs for Gram-negative bacteria are higher than those for Gram-positive cocci and usually lie above the breakpoint for resistance.
How long can you take Zyvox?
It is usually taken with or without food twice a day (every 12 hours) for 10 to 28 days. Children 11 years of age and younger usually take linezolid with or without food two to three times a day (every 8 to 12 hours) for 10 to 28 days. The length of your treatment depends on the type of infection you have.
What is the MIC of linezolid?
ABSTRACT. Linezolid showed MIC50s and MIC90s of 1 μg/ml (for both) against Staphylococcus aureus.
Is Zyvox a broad spectrum antibiotic?
Abstract. The oxazolidinones are a new class of broad spectrum chemotherapeutics of antibiotic properties. These drugs have good activity against Gram-positive pathogenic bacteria.