What is Lymphochip?
To distinguish genetic subtypes of DLBCL, the researchers created a specialized “Lymphochip,” a DNA microarray consisting of genes preferentially expressed in lymphoid cells as well as genes known to or suspected to play roles in cancer or normal immune system functions.
What is microarray gene expression analysis?
A microarray is a laboratory tool used to detect the expression of thousands of genes at the same time. DNA microarrays are microscope slides that are printed with thousands of tiny spots in defined positions, with each spot containing a known DNA sequence or gene.
What is the purpose of microarray?
The DNA microarray is a tool used to determine whether the DNA from a particular individual contains a mutation in genes.
How accurate is microarray testing?
Overall, microarray was successful in 98.8% of cases (4340 of 4391). The microarray analysis was performed on uncultured samples for 3860 (87.9%) of the 4391 participants.
What are DNA microarray assays?
The DNA microarray is a tool used to determine whether the DNA from a particular individual contains a mutation in genes like BRCA1 and BRCA2. The chip consists of a small glass plate encased in plastic. Some companies manufacture microarrays using methods similar to those used to make computer microchips.
What disease usually is expressed in a DNA microarray?
A DNA microarray is a plastic chip or glass slide that has been “printed” (spotted at precise locations) with thousands of short, single-stranded pieces of DNA for known genes. Cancer causing genes because they are more expressed in cancerous colon cells than in normal colon cells.
What diseases does microarray test for?
Chromosomal microarray (CMA) is increasingly utilized for genetic testing of individuals with unexplained developmental delay/intellectual disability (DD/ID), autism spectrum disorders (ASD), or multiple congenital anomalies (MCA).
What can a microarray not detect?
A microarray is the recommended first line genetic test for developmental delay (DD), intellectual disability (ID) and autism spectrum disorders (ASD)*. CMA however, does not identify fragile X syndrome (FXS), a common cause of intellectual disability.
What is microarray used for?
How does microarray analysis work?
Microarray technology is a general laboratory approach that involves binding an array of thousands to millions of known nucleic acid fragments to a solid surface, referred to as a “chip.” The chip is then bathed with DNA or RNA isolated from a study sample (such as cells or tissue).